Local healthcare professionals, patients and the public have submitted 55 questions to this year’s PenCLAHRC prioritisation process. This aims to identify areas of research that reflect the real issues faced by the health service across the South West – and is one of the ways we ensure our work programme is aligned to the needs and concerns of our partners. Questions, which could be submitted independently via a web tool or by attending designated Making Sense of Evidence workshops, were submitted by a variety of organisations and individuals, and span a wide range of topic areas – from social care, data handling, the development of interventions, and how to choose between different treatment options, amongst others. In a process supported by our Evidence Synthesis Team, submitted questions are now going through a multi-stage process with stakeholders who represent the collaboration. The aim is to prioritise those questions to potentially develop into research projects, with the process culminating in a Stakeholder Prioritisation Meeting in March. Where there appears to be evidence to answer a question, this will be fed back to those who raised the uncertainty. Any other questions not prioritised by the collaboration will be shared with the Research Design Service and wider NIHR for consideration. The prioritisation process has been running since PenCLAHRC first formed in 2008 and is just one of the ways that we ensure our research programme represents the needs of our stakeholders and patients across Devon, Cornwall and Somerset. The Stakeholder Prioritisation Event will be held on Friday 3 March 2017 and the outcomes of this will be communicated shortly after.