Stroke is a leading cause of death and disability with over 85,000 people hospitalised in the UK each year. One way of treating stroke and preventing disability is to give a patient medication to break down blood clots. This is called thrombolysis.
However, thrombolysis is not suitable for all patients and can be risky. For thrombolysis to be useful it needs to be given as soon after the stroke as possible. Use of thrombolysis varies hugely, even for patients with similar treatment pathways and with similar characteristics; some hospitals rarely use it while some use it in a quarter of stroke patients. The speed of giving thrombolysis also varies, with some hospitals taking an average of 90 minutes and others taking less than 40 minutes to administer the drug.
Using modern computer science techniques of clinical pathway modelling and machine learning, we will aim to find out why there is so much variability in the use of thrombolysis. This will help hospitals understand what they can do to optimise its use.
Based on the decisions made by highly qualified qualified stroke experts we will build a tool for assisting doctors to review of their use of thrombolysis. This will be particualarly useful to hospitals without sufficient funding to employ a team of expert stroke physicians.
Study Design: The research team will use a state-of-the-art computer modelling technique – pathway modelling – to better understand what causes variation in care across the UK. This approach replicates, in a computer model, the flow of patients through the first few hours of stroke care, mimicking the same processes and timings that the stroke unit currently provides. This allows us to look at the effect of changing key aspects of patient flows in a controlled, modelled environment, without affecting real patients. A second technique called ‘machine learning’ enables us to teach a computer the likely decision made in any hospital given any particular patient.
Both approaches allow us to ask ‘what if?’ questions, such as ‘what if a hospital improved diagnosis of patients by asking more questions, but by doing so extended patients’ waiting times for scans?’. With machine learning we can ask ‘what if the decisions at all hospitals were similar to hospitals that are considered centres of excellence for stroke care?’. By asking these types of questions we can identify changes at each hospital of most benefit to patients. Both techniques have been piloted across seven hospitals.
We would now like to test and refine these methods across all stroke units in England. A researcher will interview doctors to understand their attitudes to thrombolysis, and how the results from the modelling work can best be presented to them in a way that will influence more consistent stroke care across the UK.
We are conducting this work with the National Stroke Audit, hosted by the Royal College of Physicians. Our aim is to build these new advanced analytic tools into the quarterly stroke audit, helping hospitals understand whether their use and speed of thrombolysis is different from that expected for their patient population, and what changes would most improve performance (if needed).
Apply for funding to:
– Expand the machine learning to predict the probability of a good outcome, and probability of adverse effects of thrombolysis
– Conduct further qualitative research with clinicians from different hospitals with a focus on most useful outputs from this work for clinicians
– Explore the cost-effectiveness of making organisational changes to the care pathway, demonstrating benefits in health economic terms such as Quality Adjusted Life Years
– Include organisational features to address whether hospitals have insufficient infrastructure for an effective stroke pathway which might strengthen the argument for more investment in the stroke pathway
Updating estimates of the number of UK stroke patients eligible for endovascular thrombectomy: incorporating recent evidence to facilitate service planningDownload the Paper
National implementation of reperfusion for acute ischaemic stroke in England: How should services be configured? A modelling studyDownload the Paper
Use of Clinical Pathway Simulation and Machine Learning to Identify Key Levers for Maximizing the Benefit of Intravenous Thrombolysis in Acute StrokeDownload the Paper
Operational Research Seeks Benefit for Stroke VictimsDownload the ARC BITE
Can clinical audits be enhanced by pathway simulation and machine learning? An example from the acute stroke pathway.Download the Paper
- Andy Salmon, University of Exeter
- Penny Thompson, PenARC Patient & Public Engagement Group Member
- Zhivko Zhelev, University of Exeter
- Julia Frost, University of Exeter
- Charlotte James, University of Exeter